| Protein Name | HIF prolyl hydroxylase |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 40633 |
| Gene Symbol | Hph |
| UniProt | Q8SX21 (Q8SX21_DROME), Q8I0C2 (Q8I0C2_DROME), Q9VN98 (Q9VN98_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
3
Total Number of Articles : 10 |
Description |
HIF prolyl hydroxylase |
| Gene Summary |
Enables peptidyl-proline dioxygenase activity. Involved in cellular response to hypoxia; positive regulation of cell growth; and protein export from nucleus. Located in nucleoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; posterior endoderm; and ventral ectoderm. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to several human genes including EGLN1 (egl-9 family hypoxia inducible factor 1) and EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Jul 2025] |
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