Protein Name SEC24 homolog B, COPII component
Organism Homo sapiens
Gene ID 10427
Gene Symbol

SEC24B

UniProt O95487 (SC24B_HUMAN), B4DTM6 (B4DTM6_HUMAN)
Relationships Total Number of functionally related compound(s) : 14
Total Number of Articles : 8
Description

SEC24 homolog B, COPII component

Gene Summary

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

synonyms
  • protein transport protein Sec24B
  • SEC24 homolog B, COPII coat complex component
  • SEC24 related gene family, member B
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Properties