| Protein Name | tight junction protein 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 27134 |
| Gene Symbol | TJP3 |
| UniProt | O95049 (ZO3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
12
Total Number of Articles : 12 |
Description |
tight junction protein 3 |
| Gene Summary |
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012] |
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| Properties | |