| Protein Name | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19058 |
| Gene Symbol | Ppp3r1 |
| UniProt | Q63810 (CANB1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
4
Total Number of Articles : 2 |
Description |
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) |
| Gene Summary |
Enables phosphatase binding activity and phosphoprotein phosphatase activity. Involved in postsynaptic modulation of chemical synaptic transmission; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle cycle. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; circulatory system development; and myelination in peripheral nervous system. Located in sarcolemma. Part of calcineurin complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is expressed in brain; heart; jaw skeleton; lung; and tooth. Used to study dilated cardiomyopathy and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Jul 2025] |
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