| Protein Name | low density lipoprotein receptor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16835 |
| Gene Symbol | Ldlr |
| UniProt | P35951 (LDLR_MOUSE), A0A1L1SRE8 (A0A1L1SRE8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
605
Total Number of Articles : 1105 |
Description |
low density lipoprotein receptor |
| Gene Summary |
Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022] |
| synonyms |
|
| Properties | |