| Protein Name | DNA methyltransferase 1 associated protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55929 |
| Gene Symbol | DMAP1 |
| UniProt | Q9NPF5 (DMAP1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 7 |
Description |
DNA methyltransferase 1 associated protein 1 |
| Gene Summary |
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
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| Properties | |