Protein Name serpin family E member 1
Organism Rattus norvegicus
Gene ID 24617
Gene Symbol

Serpine1

UniProt P20961 (PAI1_RAT)
Relationships Total Number of functionally related compound(s) : 322
Total Number of Articles : 346
Description

serpin family E member 1

Gene Summary

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • plasminogen activator inhibitor 1
  • PAI
  • PAI-1
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Properties