| Protein Name | serpin family E member 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24617 |
| Gene Symbol | Serpine1 |
| UniProt | P20961 (PAI1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
322
Total Number of Articles : 346 |
Description |
serpin family E member 1 |
| Gene Summary |
Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); metabolic dysfunction and alcohol associated liver disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |