Protein Name centromeric DNA-binding histone H3-like protein CSE4
Organism Saccharomyces cerevisiae S288C
Gene ID 853817
Gene Symbol

CSE4

UniProt P36012 (CENPA_YEAST)
Relationships Total Number of functionally related compound(s) : 17
Total Number of Articles : 23
Description

centromeric DNA-binding histone H3-like protein CSE4

Gene Summary

Enables centromeric DNA binding activity. Involved in 2-micrometer plasmid partitioning; chromosome organization; and protein localization to CENP-A containing chromatin. Located in 2-micrometer circle DNA; condensed chromosome, centromeric region; and peroxisome. Part of CENP-A containing nucleosome. Is active in kinetochore. Used to study cancer; male infertility; and oligospermia. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human CENPA (centromere protein A). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • centromeric DNA-binding histone H3-like protein CSE4
  • YKL049C
  • CSL2
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Properties