Protein Name Sp3 transcription factor
Organism Homo sapiens
Gene ID 6670
Gene Symbol


UniProt Q02447 (SP3_HUMAN), B7ZLN9 (B7ZLN9_HUMAN), Q59FX5 (Q59FX5_HUMAN), Q86TP0 (Q86TP0_HUMAN)
Relationships Total Number of functionally related compound(s) : 870
Total Number of Articles : 981

Sp3 transcription factor

Gene Summary

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

  • transcription factor Sp3
  • GC-binding transcription factor Sp3
  • specificity protein 3
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