| Protein Name | Ras protein let-60 |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 178104 |
| Gene Symbol | let-60 |
| UniProt | P22981 (LET60_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
19
Total Number of Articles : 14 |
Description |
Ras protein let-60 |
| Gene Summary |
Enables GTP binding activity; phospholipase binding activity; and protein kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Is expressed in several structures, including germ line; gonad; head neurons; pharyngeal muscle cell; and vulval cell. Used to study RASopathy and cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); hematologic cancer (multiple); and high grade glioma (multiple). Orthologous to several human genes including HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |