Protein Name arginase 2
Organism Homo sapiens
Gene ID 384
Gene Symbol

ARG2

UniProt P78540 (ARGI2_HUMAN), A0A024R6A0 (A0A024R6A0_HUMAN)
Relationships Total Number of functionally related compound(s) : 126
Total Number of Articles : 113
Description

arginase 2

Gene Summary

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

synonyms
  • arginase-2, mitochondrial
  • L-arginine amidinohydrolase
  • L-arginine ureahydrolase
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Properties