| Protein Name | lysine demethylase 5B |
|---|---|
| Organism | Mus musculus |
| Gene ID | 75605 |
| Gene Symbol | Kdm5b |
| UniProt | Q80Y84 (KDM5B_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 15 |
Description |
lysine demethylase 5B |
| Gene Summary |
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016] |
| synonyms |
|
| Properties | |