| Protein Name | slingshot protein phosphatase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 54434 |
| Gene Symbol | SSH1 |
| UniProt | Q8WYL5 (SSH1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
23
Total Number of Articles : 22 |
Description |
slingshot protein phosphatase 1 |
| Gene Summary |
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
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