Protein Name amine oxidase copper containing 2
Organism Homo sapiens
Gene ID 314
Gene Symbol

AOC2

UniProt O75106 (AOC2_HUMAN)
Relationships Total Number of functionally related compound(s) : 145
Total Number of Articles : 136
Description

amine oxidase copper containing 2

Gene Summary

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

synonyms
  • amine oxidase [copper-containing] 2
  • amine oxidase, copper containing 2 (retina-specific)
  • retina-specific copper amine oxidase
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Properties