| Protein Name | BTG anti-proliferation factor 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12228 |
| Gene Symbol | Btg3 |
| UniProt | P50615 (BTG3_MOUSE), Q52L83 (Q52L83_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
3
Total Number of Articles : 2 |
Description |
BTG anti-proliferation factor 3 |
| Gene Summary |
This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014] |
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