| Protein Name | glial cell derived neurotrophic factor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25453 |
| Gene Symbol | Gdnf |
| UniProt | Q07731 (GDNF_RAT), A7UGJ1 (A7UGJ1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
378
Total Number of Articles : 574 |
Description |
glial cell derived neurotrophic factor |
| Gene Summary |
Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cytokine production; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study alcohol dependence; alcohol use disorder; brain disease (multiple); and hyperprolactinemia. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; irritable bowel syndrome; middle cerebral artery infarction; and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; anxiety disorder; depressive disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |