| Protein Name | myosin IXB |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4650 |
| Gene Symbol | MYO9B |
| UniProt | Q13459 (MYO9B_HUMAN), Q8WVD2 (Q8WVD2_HUMAN), B0I1T6 (B0I1T6_HUMAN), Q4LE74 (Q4LE74_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
11
Total Number of Articles : 10 |
Description |
myosin IXB |
| Gene Summary |
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
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| Properties | |