| Protein Name | PHD finger protein 8 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 23133 |
| Gene Symbol | PHF8 |
| UniProt | Q9UPP1 (PHF8_HUMAN), O95327 (O95327_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
25
Total Number of Articles : 24 |
Description |
PHD finger protein 8 |
| Gene Summary |
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017] |
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| Properties | |