Protein Name HECT and RLD domain containing E3 ubiquitin protein ligase 2
Organism Homo sapiens
Gene ID 8924
Gene Symbol

HERC2

UniProt O95714 (HERC2_HUMAN), A8KAQ8 (A8KAQ8_HUMAN)
Relationships Total Number of functionally related compound(s) : 27
Total Number of Articles : 17
Description

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Gene Summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

synonyms
  • E3 ubiquitin-protein ligase HERC2
  • HECT-type E3 ubiquitin transferase HERC2
  • hect domain and RCC1-like domain-containing protein 2
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Properties