Protein Name mutS homolog 2
Organism Mus musculus
Gene ID 17685
Gene Symbol


UniProt P43247 (MSH2_MOUSE), Q3TZI5 (Q3TZI5_MOUSE)
Relationships Total Number of functionally related compound(s) : 52
Total Number of Articles : 57

mutS homolog 2

Gene Summary

Enables ATP hydrolysis activity and DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including DNA metabolic process; immune system development; and intracellular signal transduction. Located in nucleus. Part of MutSalpha complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and tail dorsal root ganglion. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

  • DNA mismatch repair protein Msh2
  • mutS protein homolog 2
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