| Protein Name | mutS homolog 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17685 |
| Gene Symbol | Msh2 |
| UniProt | P43247 (MSH2_MOUSE), Q3TZI5 (Q3TZI5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
52
Total Number of Articles : 57 |
Description |
mutS homolog 2 |
| Gene Summary |
Enables ATP hydrolysis activity and DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including DNA metabolic process; determination of adult lifespan; and intracellular signal transduction. Located in nucleus. Part of MutSalpha complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and tail dorsal root ganglion. Used to study Lynch syndrome and colorectal cancer. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |