| Protein Name | mutS homolog 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4437 |
| Gene Symbol | MSH3 |
| UniProt | P20585 (MSH3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
80
Total Number of Articles : 99 |
Description |
mutS homolog 3 |
| Gene Summary |
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011] |
| synonyms |
|
| Properties | |