Protein Name coagulation factor II, thrombin
Organism Rattus norvegicus
Gene ID 29251
Gene Symbol


UniProt G3V843 (G3V843_RAT)
Relationships Total Number of functionally related compound(s) : 836
Total Number of Articles : 1028

coagulation factor II, thrombin

Gene Summary

Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to mechanical stimulus; response to thyrotropin-releasing hormone; and response to thyroxine. Located in collagen-containing extracellular matrix and extracellular space. Used to study several diseases, including atherosclerosis; end stage renal disease; hyperhomocysteinemia; obesity; and thrombophilia (multiple). Biomarker of bacterial pneumonia; brain edema; calcium oxalate nephrolithiasis; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin). [provided by Alliance of Genome Resources, Apr 2022]

  • prothrombin
  • coagulation factor 2
  • thrombin
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