Protein Name RAB guanine nucleotide exchange factor 1
Organism Homo sapiens
Gene ID 27342
Gene Symbol

RABGEF1

UniProt Q9UJ41 (RABX5_HUMAN), A0A024RDL6 (A0A024RDL6_HUMAN), A8K3R3 (A8K3R3_HUMAN), B3KMF1 (B3KMF1_HUMAN)
Relationships Total Number of functionally related compound(s) : 30
Total Number of Articles : 44
Description

RAB guanine nucleotide exchange factor 1

Gene Summary

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]

synonyms
  • rab5 GDP/GTP exchange factor
  • RAB guanine nucleotide exchange factor (GEF) 1
  • rabaptin-5-associated exchange factor for Rab5
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Properties