| Protein Name | aminolevulinate dehydratase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 210 |
| Gene Symbol | ALAD |
| UniProt | P13716 (HEM2_HUMAN), A0A024R877 (A0A024R877_HUMAN), B7Z3I9 (B7Z3I9_HUMAN), Q6ZMU0 (Q6ZMU0_HUMAN), A0A140VJL9 (A0A140VJL9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
239
Total Number of Articles : 345 |
Description |
aminolevulinate dehydratase |
| Gene Summary |
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
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