Protein Name aminolevulinate dehydratase
Organism Homo sapiens
Gene ID 210
Gene Symbol


UniProt P13716 (HEM2_HUMAN), A0A024R877 (A0A024R877_HUMAN), B7Z3I9 (B7Z3I9_HUMAN), Q6ZMU0 (Q6ZMU0_HUMAN), A0A140VJL9 (A0A140VJL9_HUMAN)
Relationships Total Number of functionally related compound(s) : 239
Total Number of Articles : 345

aminolevulinate dehydratase

Gene Summary

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

  • delta-aminolevulinic acid dehydratase
  • aminolevulinate, delta-, dehydratase
  • porphobilinogen synthase
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