| Protein Name | neutrophil cytosolic factor 4 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4689 |
| Gene Symbol | NCF4 |
| UniProt | Q15080 (NCF4_HUMAN), A0A494BZS1 (A0A494BZS1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
132
Total Number of Articles : 116 |
Description |
neutrophil cytosolic factor 4 |
| Gene Summary |
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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