| Protein Name | sirtuin 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 75387 |
| Gene Symbol | Sirt4 |
| UniProt | Q8R216 (SIR4_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
38
Total Number of Articles : 28 |
Description |
sirtuin 4 |
| Gene Summary |
Enables NAD+ poly-ADP-ribosyltransferase activity; NAD-dependent protein lysine deacetylase activity; and lipoamidase activity. Involved in several processes, including carboxylic acid metabolic process; peptidyl-lysine deacetylation; and regulation of lipid metabolic process. Acts upstream of or within negative regulation of insulin secretion. Located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including aorta; brain; gonad; respiratory system; and thyroid gland. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |