| Protein Name | glp-1/Notch intracellular domain |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 176286 |
| Gene Symbol | glp-1 |
| UniProt | P13508 (GLP1_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
18
Total Number of Articles : 18 |
Description |
glp-1/Notch intracellular domain |
| Gene Summary |
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including cytoplasmic streaming; positive regulation of cell population proliferation; and regulation of gene expression. Located in cytoplasm; endomembrane system; and lateral plasma membrane. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including AB lineage cell; anus; germ line; neurons; and somatic nervous system. Used to study cancer and obesity. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; Alagille syndrome; Hajdu-Cheney syndrome; adult T-cell leukemia/lymphoma; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1) and NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |