Protein Name GLE1 RNA export mediator
Organism Homo sapiens
Gene ID 2733
Gene Symbol


Relationships Total Number of functionally related compound(s) : 24
Total Number of Articles : 30

GLE1 RNA export mediator

Gene Summary

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • mRNA export factor GLE1
  • GLE1 RNA export mediator homolog
  • GLE1-like protein
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