| Protein Name | GLE1 RNA export mediator |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2733 |
| Gene Symbol | GLE1 |
| UniProt | Q53GS7 (GLE1_HUMAN), B3KMG0 (B3KMG0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
24
Total Number of Articles : 30 |
Description |
GLE1 RNA export mediator |
| Gene Summary |
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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