| Protein Name | cytochrome c oxidase subunit 6A1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1337 |
| Gene Symbol | COX6A1 |
| UniProt | P12074 (CX6A1_HUMAN), H6SG15 (H6SG15_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
5
Total Number of Articles : 4 |
Description |
cytochrome c oxidase subunit 6A1 |
| Gene Summary |
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008] |
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| Properties | |