| Protein Name | FYVE and coiled-coil domain autophagy adaptor 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 79443 |
| Gene Symbol | FYCO1 |
| UniProt | Q9BQS8 (FYCO1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 11 |
Description |
FYVE and coiled-coil domain autophagy adaptor 1 |
| Gene Summary |
The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020] |
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| Properties | |