| Protein Name | Spo11/DNA topoisomerase VI, subunit A protein |
|---|---|
| Organism | Arabidopsis thaliana |
| Gene ID | 820506 |
| Gene Symbol | ATSPO11-1 |
| UniProt | Q9M4A2 (SPO11_ARATH), A0A1I9LQV8 (A0A1I9LQV8_ARATH), A0A178VGV5 (A0A178VGV5_ARATH) |
| Relationships |
Total Number of functionally related compound(s) :
5
Total Number of Articles : 5 |
Description |
Spo11/DNA topoisomerase VI, subunit A protein |
| Gene Summary |
Encodes AtSPO11-1, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. AtSPO11-1 accumulates in foci in early G2. At 1 h post-S phase, no foci are observed, but by 3 h a majority (80%) of meiocytes at this time point contain >50 foci. However, by 5 h, AtSPO11-1 foci are no longer detectable. This suggests that the protein undergoes a rapid cycle of accumulation and disappearance in meiocytes over a period of between 1 and 5 h post-S phase. |
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