| Protein Name | SLAM family member 6 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 114836 |
| Gene Symbol | SLAMF6 |
| UniProt | Q96DU3 (SLAF6_HUMAN), B4E1U5 (B4E1U5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 13 |
Description |
SLAM family member 6 |
| Gene Summary |
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
| synonyms |
|
| Properties | |