| Protein Name | aldo-keto reductase family 1 member B |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11677 |
| Gene Symbol | Akr1b1 |
| UniProt | P45376 (ALDR_MOUSE), Q3UDY1 (Q3UDY1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
157
Total Number of Articles : 160 |
Description |
aldo-keto reductase family 1 member B |
| Gene Summary |
Enables L-glucuronate reductase activity and aldose reductase (NADPH) activity. Involved in L-ascorbic acid biosynthetic process and fructose biosynthetic process. Acts upstream of or within several processes, including metanephric collecting duct development; regulation of urine volume; and renal water homeostasis. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Jul 2025] |
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