| Protein Name | activin A receptor type 2A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 92 |
| Gene Symbol | ACVR2A |
| UniProt | P27037 (AVR2A_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
24
Total Number of Articles : 18 |
Description |
activin A receptor type 2A |
| Gene Summary |
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013] |
| synonyms |
|
| Properties | |