| Protein Name | F-box protein 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 26271 |
| Gene Symbol | FBXO5 |
| UniProt | Q9UKT4 (FBX5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
16
Total Number of Articles : 14 |
Description |
F-box protein 5 |
| Gene Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008] |
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| Properties | |