Protein Name GA binding protein transcription factor subunit alpha
Organism Homo sapiens
Gene ID 2551
Gene Symbol

GABPA

UniProt Q06546 (GABPA_HUMAN), A8IE48 (A8IE48_HUMAN), Q8IYS3 (Q8IYS3_HUMAN)
Relationships Total Number of functionally related compound(s) : 33
Total Number of Articles : 29
Description

GA binding protein transcription factor subunit alpha

Gene Summary

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

synonyms
  • GA-binding protein alpha chain
  • GA binding protein transcription factor alpha subunit 60kDa
  • GABP subunit alpha
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Properties