| Protein Name | GTP dependent ribosome recycling factor mitochondrial 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 84340 |
| Gene Symbol | GFM2 |
| UniProt | Q969S9 (RRF2M_HUMAN), A0A024RAJ7 (A0A024RAJ7_HUMAN), A0A024RAK1 (A0A024RAK1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
11
Total Number of Articles : 8 |
Description |
GTP dependent ribosome recycling factor mitochondrial 2 |
| Gene Summary |
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013] |
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