| Protein Name | dickkopf WNT signaling pathway inhibitor 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 27123 |
| Gene Symbol | DKK2 |
| UniProt | Q9UBU2 (DKK2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
27
Total Number of Articles : 25 |
Description |
dickkopf WNT signaling pathway inhibitor 2 |
| Gene Summary |
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
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| Properties | |