| Protein Name | Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 177924 |
| Gene Symbol | sir-2.1 |
| UniProt | Q21921 (SIR2_CAEEL), D3YT50 (D3YT50_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
47
Total Number of Articles : 47 |
Description |
Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 |
| Gene Summary |
Enables histone H4K deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |