Protein Name collagen type I alpha 1 chain
Organism Rattus norvegicus
Gene ID 29393
Gene Symbol

Col1a1

UniProt P02454 (CO1A1_RAT)
Relationships Total Number of functionally related compound(s) : 99
Total Number of Articles : 91
Description

collagen type I alpha 1 chain

Gene Summary

Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cellular response to acetaldehyde; cellular response to epidermal growth factor stimulus; and cellular response to mechanical stimulus. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in extracellular space and secretory granule. Used to study cholestasis and metabolic dysfunction-associated steatotic liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); rheumatic heart disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • collagen alpha-1(I) chain
  • alpha-1 type I collagen
  • collagen, type 1, alpha 1
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Properties