| Protein Name | sortilin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20661 |
| Gene Symbol | Sort1 |
| UniProt | Q6PHU5 (SORT_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
46
Total Number of Articles : 39 |
Description |
sortilin 1 |
| Gene Summary |
Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and neurotensin receptor activity, non-G protein-coupled. Involved in several processes, including D-glucose import; maintenance of synapse structure; and response to insulin. Acts upstream of or within endocytosis; negative regulation of fat cell differentiation; and protein targeting to lysosome. Located in cytoplasmic vesicle membrane; plasma membrane; and trans-Golgi network transport vesicle. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and retina. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human SORT1 (sortilin 1). [provided by Alliance of Genome Resources, Jun 2025] |
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