Protein Name transglutaminase 1
Organism Homo sapiens
Gene ID 7051
Gene Symbol


UniProt P22735 (TGM1_HUMAN)
Relationships Total Number of functionally related compound(s) : 425
Total Number of Articles : 390

transglutaminase 1

Gene Summary

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

  • protein-glutamine gamma-glutamyltransferase K
  • K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase
  • TG(K)
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