| Protein Name | transglutaminase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7051 |
| Gene Symbol | TGM1 |
| UniProt | P22735 (TGM1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
425
Total Number of Articles : 390 |
Description |
transglutaminase 1 |
| Gene Summary |
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008] |
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| Properties | |