Protein Name tissue factor pathway inhibitor
Organism Mus musculus
Gene ID 21788
Gene Symbol

Tfpi

UniProt O54819 (TFPI1_MOUSE), Q8BSB7 (Q8BSB7_MOUSE)
Relationships Total Number of functionally related compound(s) : 75
Total Number of Articles : 89
Description

tissue factor pathway inhibitor

Gene Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • tissue factor pathway inhibitor
  • extrinsic pathway inhibitor
  • lipoprotein-associated coagulation inhibitor
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Properties