Protein Name glucose-6-phosphatase catalytic subunit 1
Organism Mus musculus
Gene ID 14377
Gene Symbol


UniProt P35576 (G6PC1_MOUSE)
Relationships Total Number of functionally related compound(s) : 222
Total Number of Articles : 313

glucose-6-phosphatase catalytic subunit 1

Gene Summary

The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]

  • glucose-6-phosphatase catalytic subunit 1
  • Glc-6-Pase-alpha
  • glucose-6-phosphatase, catalytic
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