| Protein Name | dedicator of cyto-kinesis 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 94176 |
| Gene Symbol | Dock2 |
| UniProt | Q8C3J5 (DOCK2_MOUSE), Q6A0A3 (Q6A0A3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
19
Total Number of Articles : 13 |
Description |
dedicator of cyto-kinesis 2 |
| Gene Summary |
Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Jun 2025] |
| synonyms |
|
| Properties | |