Protein Name splicing factor 3b subunit 3
Organism Homo sapiens
Gene ID 23450
Gene Symbol

SF3B3

UniProt Q15393 (SF3B3_HUMAN), A8K6V3 (A8K6V3_HUMAN)
Relationships Total Number of functionally related compound(s) : 6
Total Number of Articles : 6
Description

splicing factor 3b subunit 3

Gene Summary

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

synonyms
  • splicing factor 3B subunit 3
  • SAP 130
  • pre-mRNA splicing factor SF3b, 130 kDa subunit
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Properties