Protein Name elaC ribonuclease Z 2
Organism Homo sapiens
Gene ID 60528
Gene Symbol

ELAC2

UniProt Q9BQ52 (RNZ2_HUMAN), A0A0S2Z5M8 (A0A0S2Z5M8_HUMAN)
Relationships Total Number of functionally related compound(s) : 10
Total Number of Articles : 9
Description

elaC ribonuclease Z 2

Gene Summary

The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

synonyms
  • zinc phosphodiesterase ELAC protein 2
  • RNase Z 2
  • elaC homolog 2
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Properties