Protein Name acid sensing ion channel subunit 2
Organism Homo sapiens
Gene ID 40
Gene Symbol

ASIC2

UniProt Q16515 (ASIC2_HUMAN)
Relationships Total Number of functionally related compound(s) : 49
Total Number of Articles : 38
Description

acid sensing ion channel subunit 2

Gene Summary

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

synonyms
  • acid-sensing ion channel 2
  • acid sensing (proton gated) ion channel 2
  • amiloride-sensitive cation channel 1, neuronal
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Properties