| Protein Name | slit guidance ligand 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20563 |
| Gene Symbol | Slit2 |
| UniProt | Q9R1B9 (SLIT2_MOUSE), A0A140T8T2 (A0A140T8T2_MOUSE), G3UY21 (G3UY21_MOUSE), G3UYX7 (G3UYX7_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
33
Total Number of Articles : 26 |
Description |
slit guidance ligand 2 |
| Gene Summary |
The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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