| Protein Name | LDL receptor related protein 8 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7804 |
| Gene Symbol | LRP8 |
| UniProt | Q14114 (LRP8_HUMAN), A0A590UJ98 (A0A590UJ98_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
26
Total Number of Articles : 34 |
Description |
LDL receptor related protein 8 |
| Gene Summary |
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] |
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